HPV- and non-HPV-related subtypes of penile squamous cell carcinoma (SCC): Morphological features and differential diagnosis according to the new WHO classification (2015).
Identifieur interne : 000480 ( Main/Exploration ); précédent : 000479; suivant : 000481HPV- and non-HPV-related subtypes of penile squamous cell carcinoma (SCC): Morphological features and differential diagnosis according to the new WHO classification (2015).
Auteurs : Diego F. Sanchez [Paraguay] ; Sofía Ca Ete [Paraguay] ; María José Fernández-Nestosa [Paraguay] ; Cecilia Lezcano [États-Unis] ; Ingrid Rodríguez [Paraguay] ; José Barreto [Paraguay] ; Isabel Alvarado-Cabrero [Mexique] ; Antonio L. Cubilla [Paraguay]Source :
- Seminars in diagnostic pathology [ 0740-2570 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- Carcinoma, Squamous Cell (classification), Carcinoma, Squamous Cell (diagnosis), Carcinoma, Squamous Cell (virology), Diagnosis, Differential, Humans, Male, Papillomavirus Infections (complications), Penile Neoplasms (classification), Penile Neoplasms (diagnosis), Penile Neoplasms (virology), World Health Organization.
- MESH :
- classification : Carcinoma, Squamous Cell, Penile Neoplasms.
- complications : Papillomavirus Infections.
- diagnosis : Carcinoma, Squamous Cell, Penile Neoplasms.
- virology : Carcinoma, Squamous Cell, Penile Neoplasms.
- Diagnosis, Differential, Humans, Male, World Health Organization.
Abstract
The majority of penile carcinomas are squamous cell carcinomas originating in the squamous mucosa covering the glans, coronal sulcus, or inner surface of the foreskin, the 3 latter sites comprising the penile anatomical compartments. There is a variegated spectrum of subtypes of penile squamous cell carcinomas according to recent classification schemes. Currently, because of etiological and prognostic considerations, 2 morphologically and molecularly distinctive groups of subtypes of penile SCCs based on the presence of HPV were delineated. The predominant cell composition of tumors associated with HPV is the basaloid cell, which is the hallmark and best tissue marker for the virus. Tumors negative for the virus, however, are preferentially of lower grade and keratinizing maturing neoplasms with the exception of sarcomatoid carcinoma. HPV is detected in research studies by PCR or in situ hybridization (ISH) technologies, but p16 immunohistochemical stain is an adequate and less-expensive surrogate that is useful in the routine practice of pathology. The aim of this review is to demonstrate the variable morphological phenotypic expression of penile tumors separating non-HPV- and HPV-related neoplasms and to add morphological information that will justify subclassifying squamous cell carcinomas in a number of special subtypes. A brief discussion of the differential diagnosis in each category is also provided.
DOI: 10.1053/j.semdp.2014.12.018
PubMed: 25701382
Affiliations:
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Sanchez</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción, Paraguay.</nlm:affiliation><country xml:lang="fr">Paraguay</country><wicri:regionArea>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción</wicri:regionArea><wicri:noRegion>Asunción</wicri:noRegion></affiliation></author><author><name sortKey="Ca Ete, Sofia" sort="Ca Ete, Sofia" uniqKey="Ca Ete S" first="Sofía" last="Ca Ete">Sofía Ca Ete</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay.</nlm:affiliation><country xml:lang="fr">Paraguay</country><wicri:regionArea>Instituto de Patología e Investigación, Brizuela 325, Asunción</wicri:regionArea><wicri:noRegion>Asunción</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Nestosa, Maria Jose" sort="Fernandez Nestosa, Maria Jose" uniqKey="Fernandez Nestosa M" first="María José" last="Fernández-Nestosa">María José Fernández-Nestosa</name><affiliation wicri:level="1"><nlm:affiliation>Facultad Politécnica, UNA, Asunción, Paraguay.</nlm:affiliation><country xml:lang="fr">Paraguay</country><wicri:regionArea>Facultad Politécnica, UNA, Asunción</wicri:regionArea><wicri:noRegion>Asunción</wicri:noRegion></affiliation></author><author><name sortKey="Lezcano, Cecilia" sort="Lezcano, Cecilia" uniqKey="Lezcano C" first="Cecilia" last="Lezcano">Cecilia Lezcano</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh Medical Center, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Rodriguez, Ingrid" sort="Rodriguez, Ingrid" uniqKey="Rodriguez I" first="Ingrid" last="Rodríguez">Ingrid Rodríguez</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción, Paraguay.</nlm:affiliation><country xml:lang="fr">Paraguay</country><wicri:regionArea>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción</wicri:regionArea><wicri:noRegion>Asunción</wicri:noRegion></affiliation></author><author><name sortKey="Barreto, Jose" sort="Barreto, Jose" uniqKey="Barreto J" first="José" last="Barreto">José Barreto</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción, Paraguay.</nlm:affiliation><country xml:lang="fr">Paraguay</country><wicri:regionArea>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción</wicri:regionArea><wicri:noRegion>Asunción</wicri:noRegion></affiliation></author><author><name sortKey="Alvarado Cabrero, Isabel" sort="Alvarado Cabrero, Isabel" uniqKey="Alvarado Cabrero I" first="Isabel" last="Alvarado-Cabrero">Isabel Alvarado-Cabrero</name><affiliation wicri:level="1"><nlm:affiliation>Hospital de Oncología, CMN, México, México.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Mexique</country><wicri:regionArea>Hospital de Oncología, CMN, México</wicri:regionArea><wicri:noRegion>México</wicri:noRegion></affiliation></author><author><name sortKey="Cubilla, Antonio L" sort="Cubilla, Antonio L" uniqKey="Cubilla A" first="Antonio L" last="Cubilla">Antonio L. Cubilla</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción, Paraguay. Electronic address: antoniocubillaramos@gmail.com.</nlm:affiliation><country xml:lang="fr">Paraguay</country><wicri:regionArea>Instituto de Patología e Investigación, Brizuela 325, Asunción, Paraguay; Facultad de Ciencias Médicas, UNA, Asunción</wicri:regionArea><wicri:noRegion>Asunción</wicri:noRegion></affiliation></author></analytic><series><title level="j">Seminars in diagnostic pathology</title><idno type="ISSN">0740-2570</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carcinoma, Squamous Cell (classification)</term><term>Carcinoma, Squamous Cell (diagnosis)</term><term>Carcinoma, Squamous Cell (virology)</term><term>Diagnosis, Differential</term><term>Humans</term><term>Male</term><term>Papillomavirus Infections (complications)</term><term>Penile Neoplasms (classification)</term><term>Penile Neoplasms (diagnosis)</term><term>Penile Neoplasms (virology)</term><term>World Health Organization</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Carcinome épidermoïde ()</term><term>Carcinome épidermoïde (diagnostic)</term><term>Carcinome épidermoïde (virologie)</term><term>Diagnostic différentiel</term><term>Humains</term><term>Infections à papillomavirus ()</term><term>Mâle</term><term>Organisation mondiale de la santé</term><term>Tumeurs du pénis ()</term><term>Tumeurs du pénis (diagnostic)</term><term>Tumeurs du pénis (virologie)</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Penile Neoplasms</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Papillomavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Penile Neoplasms</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs du pénis</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs du pénis</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Penile Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term><term>Humans</term><term>Male</term><term>World Health Organization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Diagnostic différentiel</term><term>Humains</term><term>Infections à papillomavirus</term><term>Mâle</term><term>Organisation mondiale de la santé</term><term>Tumeurs du pénis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The majority of penile carcinomas are squamous cell carcinomas originating in the squamous mucosa covering the glans, coronal sulcus, or inner surface of the foreskin, the 3 latter sites comprising the penile anatomical compartments. There is a variegated spectrum of subtypes of penile squamous cell carcinomas according to recent classification schemes. Currently, because of etiological and prognostic considerations, 2 morphologically and molecularly distinctive groups of subtypes of penile SCCs based on the presence of HPV were delineated. The predominant cell composition of tumors associated with HPV is the basaloid cell, which is the hallmark and best tissue marker for the virus. Tumors negative for the virus, however, are preferentially of lower grade and keratinizing maturing neoplasms with the exception of sarcomatoid carcinoma. HPV is detected in research studies by PCR or in situ hybridization (ISH) technologies, but p16 immunohistochemical stain is an adequate and less-expensive surrogate that is useful in the routine practice of pathology. The aim of this review is to demonstrate the variable morphological phenotypic expression of penile tumors separating non-HPV- and HPV-related neoplasms and to add morphological information that will justify subclassifying squamous cell carcinomas in a number of special subtypes. A brief discussion of the differential diagnosis in each category is also provided.</div></front></TEI><affiliations><list><country><li>Mexique</li><li>Paraguay</li><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="Paraguay"><noRegion><name sortKey="Sanchez, Diego F" sort="Sanchez, Diego F" uniqKey="Sanchez D" first="Diego F" last="Sanchez">Diego F. Sanchez</name></noRegion><name sortKey="Barreto, Jose" sort="Barreto, Jose" uniqKey="Barreto J" first="José" last="Barreto">José Barreto</name><name sortKey="Ca Ete, Sofia" sort="Ca Ete, Sofia" uniqKey="Ca Ete S" first="Sofía" last="Ca Ete">Sofía Ca Ete</name><name sortKey="Cubilla, Antonio L" sort="Cubilla, Antonio L" uniqKey="Cubilla A" first="Antonio L" last="Cubilla">Antonio L. Cubilla</name><name sortKey="Fernandez Nestosa, Maria Jose" sort="Fernandez Nestosa, Maria Jose" uniqKey="Fernandez Nestosa M" first="María José" last="Fernández-Nestosa">María José Fernández-Nestosa</name><name sortKey="Rodriguez, Ingrid" sort="Rodriguez, Ingrid" uniqKey="Rodriguez I" first="Ingrid" last="Rodríguez">Ingrid Rodríguez</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Lezcano, Cecilia" sort="Lezcano, Cecilia" uniqKey="Lezcano C" first="Cecilia" last="Lezcano">Cecilia Lezcano</name></region></country><country name="Mexique"><noRegion><name sortKey="Alvarado Cabrero, Isabel" sort="Alvarado Cabrero, Isabel" uniqKey="Alvarado Cabrero I" first="Isabel" last="Alvarado-Cabrero">Isabel Alvarado-Cabrero</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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